摘要
肠道病毒71型（EV71）是引起手足口病的主要病原体之一，已经引起世界各地的大范围流行，可引起严重的并发症并导致患儿死亡。其引起严重并发症的致病机制尚不清楚，与许多因素有关包括细胞趋向、细胞凋亡和宿主免疫反应。该文主要介绍决定EV71细胞趋向的因素，引起细胞凋亡的相关机制及宿主免疫反应在EV71致病机制中的作用。
Enterovirus 71 （ EV71 ） is one of the major pathogens that cause hand foot and mouth dis-ease. Epidemics and pandemics have been periodically reported worldwide. EV71 also can cause serious compli-cations and lead death in children. The mechanisms of EVT1 cause serious complications has remained unclear, may relate to many factors, including cell tropism, cell death and host immune responses. This article reviews the recent advances in the identification of factors determining EVT1 cell tropism, the associated mechanisms of viral infection-induced cell death and the interplay between EVT1 and immunity.
出处
《国际儿科学杂志》
2013年第1期68-70,共3页
International Journal of Pediatrics
