摘要
目的:探讨急性一氧化碳中毒(ACOP)患者血清中内皮索(ET)、一氧化氮(NO)水平的变化及意义。方法:选择不同中毒程度的ACOP患者75例.于入院即刻抽血,分别测定血中ET、NO浓度;选健康对照组25例。结果:中、重度ACOP患者血清ET水平明显高于正常健康对照组及轻度中毒组;轻度中毒组与正常对照组比较差异不明显(P>0.05),轻度与中度中毒组比较差异有显著性(P<0.05),中度与重度中毒组比较,ET水平均升高,但两者差异不具有统汁学意义(P>0.05):NO的变化与之相反。ET与NO之间存在负相关关系(r=0.606.P<0.05)。结论:ACOP时NO水平降低,ET水平升高,NO ET比例失调,加重微血管痉挛,加重组织缺血缺氧,在ACOP病理过程中起着重要作用。
Purpose: To investigate the changes and significance of nitric oxide(NO) and endothelin(ET) in patients with acute carbon monoxide poisoning(ACOP). Method: The concentration of NO. ET were determined respectively in 75 cases of ACOP group and 25 cases of normal control. Results: The concentrations of peripheral venous blood ET( serum) in moderate and severe group were significantly elevated as compare with that of mild and normal group( P <0. 05). In comparing of moderate and advance poisoning group ET levels all are elevate,but without significance( P >0. 05). The change of NO was reverse to that of ET. The level of NO was negatively correlated with ET(r = 0. 606. P <0. 05). Conclusion: The imbalance of ET and NO takes part in the pathological process of ACOP.
出处
《临床急诊杂志》
CAS
2003年第2期3-4,共2页
Journal of Clinical Emergency
