摘要
目的 探讨急性一氧化碳中毒 (ACOP)患者血清丙二醛 (MDA)水平、谷胱甘肽过氧化物酶 (GSH -Px)及超氧化物歧化酶 (SOD)活性的变化 ,了解ACOP时自由基氧化损伤在其病理机制中的作用。方法 选择不同中毒程度的ACOP患者70例 ,分别于入院即刻、12、2 4、4 8、72h抽血测定血清中MDA水平及SOD、GSH -Px的活性。结果 ACOP时 ,中度CO中毒组与轻度中毒组比较 ,血清MDA水平升高 ,但不具有显著性意义 (P >0 0 5 ) ;重度中毒组与中度中毒组比较 ,MDA水平显著性升高 (P <0 0 5 ) ,且 2 4、4 8h仍维持在较高水平。中度中毒组与轻度中毒组比较 ,血清SOD及GSH -Px活性水平降低 ,但不具有显著性意义 (P >0 0 5 ) ;重度中毒组与中度中毒组比较 ,SOD及GSH -Px活性水平显著性降低 (P <0 0 5 )。结论 ACOP时血清MDA水平升高 ,SOD及GSH -Px活性降低 ,提示ACOP时存在着严重自由基氧化损伤的病理过程 ,为ACOP治疗过程中抗氧化治疗提供了依据。同时 ,血清MDA水平和SOD及GSH -Px活性也可作为中毒损伤程度评估、预后判定的指标之一。
Objective To study the change and role of serum malonyldialdehyde(MDA),superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in patients with acute carbon monoxide poisoning(ACOP).Methods 70 cases of ACOP were observed,and divided into mild, moderate and severe group.Serum SOD,GSH-Px activity and MDA concentration were measured respectively at 0,12,24,48 and 72 h after ACOP.Results Compared with mild and moderate group, the concentration of MDA in severe group were significantly increased ( P <0 05).Compared with mild and moderate group, the activity of SOD and GSH-Px in severe group were significantly declined ( P <0 05).Conclusion Serum MDA concentration would be increased after ACOP.SOD and GSH-Px activity would be declined.The demonstrated free radicals injury might play an important role in pathogenesis resulting from CO poisoning.It might be one of the reference index to ACOP.
出处
《中国急救医学》
CAS
CSCD
北大核心
2003年第4期221-222,共2页
Chinese Journal of Critical Care Medicine
