摘要
目的 :观察奥曲肽或垂体后叶素、一次硬化剂注射、心得安序贯治疗食管静脉曲张出血的近期及远期疗效。方法 :1 38例病人分为三组。三组病人均先静脉使用奥曲肽或垂体后叶素 ,之后分别接受单纯心得安治疗 (心得安组 )、一次硬化剂注射治疗后继以心得安治疗 (硬化剂 +心得安组 )、多次硬化剂注射治疗 (硬化剂组 )。比较三组病人的平均止血时间、近期再出血率、远期再出血率、平均住院日数及并发症发生情况。结果 :硬化剂 +心得安组、硬化剂组的平均止血时间分别为 1 5 .1± 1 .9h ,1 4 .8± 1 .9h ,比心得安组的 1 9.9± 4 .6h短(均P <0 .0 1 )。但硬化剂 +心得安组与硬化剂组间比较无差异。近期再出血率硬化剂组较心得安组低 (P <0 .0 5) ,硬化剂 +心得安组与硬化剂组间比较及心得安组与硬化剂 +心得安组间比较无差异。远期再出血率硬化剂 +心得安组及硬化剂组均较心得安组低 (P分别为 <0 .0 5 ,<0 .0 1 ) ,硬化剂 +心得安组与硬化剂组间比较无差异。平均住院日数则硬化剂组较其余两组长 (均P <0 .0 1 ) ,而硬化剂 +心得安组与心得安组间比较无差异。结论 :奥曲肽或垂体后叶素、一次硬化剂注射、心得安序贯治疗食管静脉曲张出血的疗效与多次硬化剂注射治疗相似 ,是较好的治疗食管静脉曲张出血及预防再出?
Objective:To evaluate the therapulic effects of sequentical treatment with Octreotide or Pituitrin, single scleroinjection, propranolol on esophageal varical bleeding. Methods:One hundred and thirty-eight cirrhosis patients with acute esophageal varical bleeding were divided into three groups. There are the propranolol group treated with Octreotide or Pituitrin and propranolol, the scleroinjection and propranolol group treated with Octreotide or Pimitrin and single scleroinjection and propranolol and the scleroinjection group treated with Octreotide or Pituitrin and repetitious scleroinjections. To compare their duration of hemostatsis,rebleeding, average admission days. Results:The hemostic times of the scleroinjection group and the scleroinjection and propranolol group (15.1±1.9hours, 14.8±1.9 hours) were shorter than the propranolol group's (19.9±4.6hours), P <0.01. But there were no significant difference between the scleroinjection and propranolol group and the scleroinjection group. The rebleeding rate of the propranolol group in 1 week was higher than the scleroinjection group's( P <0.05).The rebleeding rate of the propranolol group in 1 year was higher than the scleroinjection group and the scleroinjection and propranolol group 's( P <0.05, P <0.01). The average admission days of the scleroinjection group was longer than other groups' s( P <0.01). But there were no significant difference between the scleroinjection and propranolol group and the scleroinjection group.Conclusions: The effects of sequentical treatment with single scleroinjection and propranolol was similar to repetitious scleroinjection.It is an effective method to control and prevent the esophageal varical bleeding.
出处
《中国内镜杂志》
CSCD
2003年第3期51-52,58,共3页
China Journal of Endoscopy
