摘要
目的 探讨不同剂量的善宁治疗肝硬化门脉高压食管胃底曲张静脉破裂出血的疗效并进行比较。方法 将观察病人78例随机分成3组,共67例完成试验,分别给予不同剂量的善宁治疗方案。3组均首先给予善宁0.1mg静脉注射,之后再持续静脉滴注善宁维持72h.维持剂量分别为:A组:0.015mg/h,B组:0.025mg/h,C组:0.035mg/h。分别观察3组的12h、12～24h的止血情况,并观察用药时的副作用和停药后7天内的再出血率。结果 A、B、C 3组12h内止血率分别为60.00％、63.64％和64.00％;24h内总止血率分别为85.00％、86.36％和88.00％,3组比较疗效相当,无统计学差异(P>0.20);3组均未出现明显的副作用;再出血率分别为10.00％、13.64％和12.00％,3组之间比较无统计学差异(P>0.05)。结论 3组剂量疗效相当,比常规剂量(0.025～0.050mg/h)小的善宁剂量对肝硬化食管胃底曲张静脉破裂出血也有较好的止血效果,因此善宁的有效剂量范围仍需一进步探索。
Objective To investigate the effect of different dosage of somatostin esophageal variceal bleeding. Methods 78 cases were randomly divided into three groups: A, B and C, hut 67 cases finished the experiment completely. 67 patients in three groups received an intravenous injection of 0.1 mg somatostin first, then followed by continuous intravenous drip of somatostin at a constant speed of 0.015 mg/h,0.025 mg/h and 0.035 mg/h for 72 hours in group A,B and C respectively.It will be observered stoping hemorrhage at 12 h, 12 - 24 h,rebleeding after sloped manipulation at 7 d and occurring side-effecl.Results 12 h hemostasis rates in group A,group B and group C were 60.00% ,63.64% and 64.00% respectively; 12 - 24 h hemomstasis rates were 85.00% , 86.86%and 88.00% respectively;rebleeding rates were 10.00% ,13.64% and 12.00% respectively.There were no significant side- effect in three groups. There were no statistically significant difference among the three groups in terms of the homostasis rales and rebleeding rates( P > 0.05). Conclusion The smaller dosage somatostin than routine dosage of somatostin is also effective in the management of acute esophageal variceal bleeding. The effective dosage arrange of somatostin need exploring further more.
出处
《疑难病杂志》
CAS
2002年第1期10-11,共2页
Chinese Journal of Difficult and Complicated Cases
