摘要
目的 :研究中药复方制剂芪丹通脉片 (QDTMT)对心肌损伤大鼠血小板功能的影响 .方法 :用QDTMT给SD大鼠连续灌胃 14d ,第 12日起动物皮下注射ISO(4 8μmol·kg-1d-1) ,每日一次 ,连续 3d ,复制心肌损伤大鼠模型 .结果 :中药复方制剂QDTMT能明显减轻心肌损伤程度 ,抑制血小板聚集功能 ,降低血浆血栓素B2 (TXB2 )水平 ,提高 6 酮 前列腺素(6 keto PGF1α)水平和 6 keto PGF1α/TXB2 比值 ,与模型组相比有显著性差异 (P <0 .0 5 ,P <0 .0 5 ,P <0 .0 5和P <0 .0 1) .结论 :QDTMT可能通过抑制血小板活化 。
AIM: To study the effects of Qidantongmai tablet (QDTMT ), a compound preparation made up of pure traditional Chinese medicine, on platelet function in rats with myocardial injury. METHODS: The suspension of QDTMT was administered to SD rats by gastrogavage for 14 days and from the 12th day rats were given subcutaneous injection of isoproterenol (ISO, 48 μmol·kg -1 d -1 ) once per day for three days, thus establishing the myocardial injury model. RESULTS: Compared with model group, the group treated with QDTMT markedly alleviated the myocardial injury, inhibited platelet aggregation, decreased thromboxane B 2(TXB 2)level and increased 6 keto prostaglandin F 1α (6 keto PGF 1α ) level and 6 keto PGF 1α /TXB 2 ratio ( P <0.05, 0.05, 0.05, 0.01). CONCLUSION: The results show that QDTMT can inhibit the activation of platelet function and regulate the equilibrium of prostaglandin and thromboxane to prevent myocardial injury.
出处
《第四军医大学学报》
北大核心
2003年第5期406-408,共3页
Journal of the Fourth Military Medical University
基金
陕西省重点科研项目资助课题 (2 0 0 1K1 2 G7)
