摘要
目的 在心理应激条件下 ,观察大鼠组织中金属硫蛋白 (MT)水平的变化及其与锌营养状况的关系。方法 6 0只雄性Wistar大鼠随机分为 6组 :缺锌组 (ZD)、喂对组 (PF)、对照组 (CT) ,以及相应的 3个应激组 (SZ、SP、SC)。以光 -电刺激方法建立心理应激动物模型 ,观察应激对皮质醇激素、锌和金属硫蛋白的影响。结果 应激诱导动物脑和肝脏MT含量增加 ,而血浆锌出现不同程度下降。缺锌动物血锌浓度降低 ,肝脏和脑中金属硫蛋白的含量减少 ,而其整体应激反应强度增加。结论 维持良好的锌营养状况有助于诱导整体和脑组织产生应激蛋白 ,并提高机体对心理应激的适应能力。
Objective To observe the changes of metallothionein and cortisol of rats in different zinc nutriture under psychological condition.Methods Sixty rats were divided into six groups:zinc deficient(ZD),pair-fed(PF),control(CT) and the corresponding 3 stress groups(SZ,SP,SC).The psychological stress was induced by light-electric stimuli.Results The stressor induced more MT synthesis in brain and liver tissues while the zinc concentrations decreased to some extent in the stress animals.The zinc concentrations in sera,the MT contents in both liver and brain were decreased while the cortisol levels were increased in ZD groups.Conclusion It was indicated that maintaining adequate zinc nutriture was beneficial to induce the synthesis of MT in brain and liver of the rats,and to enhance their adapting ability to psychological stress.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2003年第4期385-386,共2页
Chinese Journal of Public Health
基金
国家自然科学基金资助课题 (39970 642 )
