摘要
目的 :研究谷氨酰胺 (Gln)和重组人生长激素 (rhGH)治疗肝、肾移植后低蛋白血症的效果。 方法 :术后不同时期内发生低蛋白血症的 10例肝移植和 12例肾移植病人 ,每天接受含有 10 0ml丙氨酰 谷氨酰胺 (Ala Gln)二肽的肠外营养支持 (PN) ,连续 12～ 17天 ;每天给予rhGH 4U皮下注射 ,连续 12～ 17天。治疗前和治疗后的第 7、14和2 1天 ,分别检测血中白蛋白 (Alb)、总蛋白 (TP)的变化。 结果 :2 2例病人接受PN +Gln +rhGH治疗后的第 7、14和2 1天 ,血清Alb和TP均有不同程度的升高 ,其中第 14和 2 1天检测的Alb和TP水平与术前比差异显著。另有 2例并发肠瘘的病人由于低蛋白血症的纠正而自行愈合。 结论 :PN配以Gln和rhGH可有效地纠正肝、肾移植后的低蛋白血症。
Objectives: To investigate the effect of parenteral nutrition(PN), glutamine (Gln) and growth hormone in ametiorating hypoproteinemia after liver and kidney transptantation. Methods: Ten liver transplantation recipients and 12 kidney transplantation recipients with hypoproteinemia received parenteral nutrition supplemented with alanyl glutamine dipeptide (Ala Gln, 100 ml/d) and recombined human GH(rhGH, 4 U/d) for 12～17 days. Serum albumin (Alb) and total protein (TP) were determined respectively before and days 7,14 and 21 after therapy. Results:On the days 7 and 14 after therapy,the serum levels of Alb and TP were elevated. Statistic analysis showed that Alb and TP on the days 14 and 21 had a significant increase when compared with that before therapy( P < 0.05 ). Another 2 patients with intestinal fistula due to their hypoproteinemia cured with no operation. Conclusions: PN Combined with Gln and rhGH could ameliorate hypoproteinenia after liver and kidney transplantation.
出处
《肠外与肠内营养》
CAS
2003年第2期103-105,共3页
Parenteral & Enteral Nutrition
关键词
肝、肾移植
低蛋白血症
谷氨酰胺
生长激素
Liver,kidney transplantation
Hypoproteinemia
Glutamine
Growth hormone
