摘要
目的 探讨c -myc和增殖细胞核抗原 (PCNA)在甲状腺良、恶性肿瘤组织中的表达及其诊断意义。方法 应用免疫组化法 ,检测 2 8例甲状腺腺瘤和 3 0例甲状腺癌组织中c -myc和PCNA的表达。 结果 c -myc和PCNA在腺癌组织中阳性表达率分别为 90 .0 % (2 7/3 0 )和 80 .0 % (2 4/3 0 ) ,显著高于腺瘤组织分别为 42 .9% (12 /2 8) ,5 3 .6% (15 /2 8) ,P <0 .0 5。腺瘤组织中c -myc主要表达于细胞核 ,阳性率为 83 .3 % ;而腺癌组织则多表达于细胞质 ,阳性率为 88.9%。甲状腺肿瘤中c -myc表达和PC NA表达无相关性。结论 检测c -myc、PCNA的表达有助于甲状腺肿瘤良恶性的鉴别诊断 ;甲状腺肿瘤中c
Objective To study the diagnostic value of c Myc and proliferating cell nuclear antigen(PCNA)in the benign and malignant thyroid neoplasms.Methods Expressions of C Myc and PCNA were detected in 28 thyroid adenomas and 30 thyroid carcinomas by immunohistochemical method.Results The positive rate of c Myc and PCNA was significantly higher in thyroid carcinoma than those in thyroid adenoma(90.0% and 80.0% VS 42.9% and 53.6%,respectively)( P <0.05).C Myc was mainly located in nuclear of tumor cells in thyroid adenomawith a positive rate of 83.3%.,while c Myc was mainly located in cytoplasm of tumor cells in thyroid carcinoma,with a positive rate of 88.9%.No correlation was observed between c Myc and PCNA expression in thyroid neoplasm.Conclusion The detection of c My and PCNA is valuable to differentiate between benign and malignant neoplasm of thyroid gland,and there is no synergy between c Myc and PCNA expression in thyroid neoplasm.
出处
《实用癌症杂志》
2003年第2期163-165,共3页
The Practical Journal of Cancer
