摘要
目的:研究细胞周期蛋白B1、癌基因C-erbB-2和雌激素受体(ER)、孕激素受体(PR)在乳腺癌中的表达情况及临床意义.方法:采用S-P免疫组化方法对65例乳腺癌组织和15例乳腺纤维瘤组织进行cy-clinB1、C-erbB-2和ER、PR表达的联合检测.结果:乳腺癌组织中CyclinB1过阳性表达率为84.62%(55/65);乳腺纤维瘤组织CyclinB1表达率为13.3%(2/15);淋巴结转移患者CyclinB1蛋白的过阳性表达率明显高于淋巴结阴性患者;CyclinB1的表达与C-erbB-2表达具有相对的一致性,CyclinB1的阳性高表达伴随ER表达降低,但与PR的表达无显著相关性.结论:CyclinB1的过表达与乳腺癌的发生、发展相关,过表达cy-clinB1可为乳腺癌早期诊断和生物学行为的判断提供帮助.CyclinB1与C-erbB-2和ER、PR的联合检测有利于指导乳腺癌的化疗和判断预后.
Objective： To study the expression of cyclinB1, C- erbB - 2, ER and PR in breast cancer and to evaluate their clinical significance. Methods： Immunohistochemical method was used to analyze the expression of cyclinB1, C - erbB - 2, ER and PR in breast cancer. Results： Positive rate of overexpression of cyclinB1 in breast cancer was 86.24 %, in fibroadenoma of breast the expression rate was 13.3%, statistically significant difference was found between two groups. The expression of cyclinB1 was significantly increased in breast cancer with metastasis compared with that without metastasis. High co- expression of cyclinB1 and C- erbB - 2 was found in tumor cells . The expression of ER was decreased in the patients with high expression of cyclinB1, and there was no relationship between the expression of cyclinB1 and PR. Conclusion： Overexpression of eyclinB1 is involved in carcinogenesis and development of breast cancer, and the detection of correlative expression of cyclinB1, ER, PR and C - erbB - 2 may have advantages for the choice of therapeutic scheme.
出处
《内蒙古民族大学学报（自然科学版）》
2006年第2期197-200,共4页
Journal of Inner Mongolia Minzu University：Natural Sciences
