摘要
目的 采用反相高效液相色谱法测定格列美脲胶囊的溶出度。方法 选用ODS柱 ,流动相为甲醇 -磷酸二氢铵溶液(8∶3) ,检测波长 2 2 8nm。结果 格列美脲在 0 .0 4 11～ 3.0 84 μg范围内呈良好的线性关系 (r=0 .999) ,平均回收率 10 1.1% ,RSD =1.5 3%。结论 该方法操作简单 ,准确快速 ,可用于格列美脲胶囊的溶出度测定。
OBJECTIVE An RP-HPLC method was used for determining glimepiride dissolution from Glimepiride capsules.METHODS An ODS column,Methanol-Ammonium dihydrogen phosphate(8∶3)were used.The detection wavelength was 228 nm.RESULTS The calibration curves showed good linearity over the range of 0.0411-3.084 μg( r =0.9999) The average recovery was 101.1% with RSD = 1.53% .CONCLUSION The method was simple,accurate and rapid.
出处
《华西药学杂志》
CAS
CSCD
2003年第2期137-139,共3页
West China Journal of Pharmaceutical Sciences
