摘要
目的:以外周动脉超声法,研究喂养高胆固醇高脂不同时间兔的血管内皮功能。方法:12只雌雄各半的日本大耳白兔,随机分为对照组(NC组)和高胆固醇高脂饮食组(HC组),分别于喂养0、1、2、4、6、8、10、12和14周,以外周髂外动脉超声法,测定血管内皮依赖性舒张功能(EDD)和内皮非依赖性舒张功能(NEDD)。结果:高胆固醇高脂喂养兔1周后,EDD即已发生损害,随着喂养的继续,EDD进一步损害,喂养8周后,NEDD才发生障碍。结论:高胆固醇高脂喂养兔的血管内皮功能明显障碍,EDD障碍发生的时间明显早于NEDD。
Objective: To study the vascular endothelial function in atherogenic diet fed rabbits during a variety of feeding time. Methods: 12 Japanese big- eared rabbits were fed either a normal control diet or an atherogenic diet (containing 1 % cholesterol,5% lard and 2% yolk) for 14 weeks. At different feeding times (week0, 1,2,4,6,8,10,12,14),vascular endothelial functions ,including endothelial dependant dilation (EDD) and non- endothelial dependant dilation (NEDD) were measured with high- resolution ultrasound. Results: EDD dysfunction occurred after 1 week of atherogenic diet feeding. With continued feedings ,EDD dysfunction was progressively worse. NEDD dysfunction occurred at week 8,much later than EDD dysfunction. Conclusion :Vascular endothelial functions including EDD and NEDD in atherogenic diet fed rabbits were seriously damaged. EDD dysfunction occurred much earlier than NEDD dysfunction.
出处
《重庆医科大学学报》
CAS
CSCD
2003年第1期25-28,共4页
Journal of Chongqing Medical University
关键词
高胆固醇
高脂
超声检测
高脂血症
血管功能
内皮功能
Hypercholesterolenlia
Vascular function
Endothelial function
High - resolution ultrasound
