摘要
目的:探讨复方虎杖颗粒对冠心病患者血管内皮依赖性舒张功能障碍(EDD)的干预效应。方法:因胸闷和/或胸痛在我院经冠状动脉造影检查确诊为冠状动脉粥样硬化性心脏病、且高分辨血管超声检查发现血管内皮依赖性舒张功能障碍(以血流介导的肱动脉扩张率FMD表示)者24例,随机分为冠心病组(CAD组)和虎杖治疗组(HZ组),每组各12例。HZ组给予复方虎杖颗粒10g/次,1日3次,共用药14天,分别测定用药前及用药14天后FMD(EDD0和EDD14)。同时设年龄和性别相匹配的正常对照12例(NC组)。结果:EDD0和EDD14在NC组分别为(11.76±0.95)%和(11.83±0.70)%,CAD组分别为(5.37±1.15)%和(5.50±1.01)%,较NC组差异显著,HZ组分别为(5.62±1.22)%和(9.84±1.83)%,均较NC组明显降低,且服用复方虎杖颗粒后EDD较服药前有明显改善,差异有显著性(P<0.05),较NC组无明显差异。结论:复方虎杖颗粒可明显改善冠心病患者血管内皮依赖性舒张功能。
Objective： To investigate the intervention effect of the compound polygonum cuspidatum sieb. et Zucc. grain on endothelium dependent dysfunction in patients with coronary artery disease.Methods ： Twenty-four patients with both confirmed diagnosis of coronary artery disease （diagnosed by coronary arteriography） and endothelium dependent dilation （EDD） [expressed by flow mediated dilation （FMD） examined through high-resolution ultrasound] were enrolled into this investigation. They were divided into Group CAD, and Group HZ at random. Each group consisted of 12 patients. Group HZ ,was administered the compound polygonum cuspidatum sieb. et Zucc, grain 10 grams per time, three times a day for 14 consecutive days. EDD0 and EDD14 were examined before and after the administration of the compound polygonum cuspidatum sieb. et Zucc. grain for 14 days. Group of normal control （Group NC） consisted of 12 age- and sexmatched healthy people.Results：EDDO and EDD14 were （11.76 ±0.95）% and （11.83±0.70）% in Group NC, （5.37 ± 1.15）% and （5.50± 1.01）% in Group CAD which had significant difference compared with Group NC, （5.62 ±1.22）% and （9.84 ±1.83）% in Group HZ which were significantly different from those in Group NC.In GroupHZ ,EDD14 was higher than EDDO and had no significant difference compared with Group NC.Conclusion：The compound polygonum cuspidatum sieb.et Zucc.grain can improve endothelium-dependent dysfunction in patients with coronary artery disease.
出处
《重庆医科大学学报》
CAS
CSCD
2006年第6期877-878,901,共3页
Journal of Chongqing Medical University
关键词
虎杖
内皮功能
冠心病
高分辨超声
Polygonum cuspidatum sieb. et Zucc
Endothelial function
Coronary artery disease
High-resolution ultrasound
