摘要
目的 探讨胰岛素抵抗是否为所研究高血压大家系的遗传中间表型 ,研究胰岛素抵抗与高血压关系。方法 我们在北京石景山区收集到一个高血压大家系 ,共 4代约 2 2 0人 ,以该高血压大家系成员为观察对象 ,检测其空腹血糖 (FPG) ,血脂 ,血浆胰岛素 (FINS) ,计算胰岛素抵抗指数 (IR)反映胰岛素抵抗的情况。结果 该家系直系成员高血压组和血压正常组IR值都显著高于家族旁系血压正常 (亦无高血压家族史 )组。Logistic回归分析显示在家族直系成员中 ,年龄为影响血压的主要因素 ,旁系中年龄 ,IR为影响血压的主要因素 ,而以IR对血压的影响最大。结论 胰岛素抵抗对该高血压大家系血压水平有一定影响 ,能否作为其遗传中间表型尚需进一步研究 ,但在该家系居住的同一地区人群中 ,胰岛素抵抗是影响血压的重要危险因素 。
Objective To study if insulin resistance is the intermediate phenotype of hypertension in a great family, to explore the association of insulin resistance with hypertension. Methods Concentrations of fasting plasma glucose, blood lipid and insulin were measured in all members of this family, and the power of insulin resistance was indicated with IR which calculated in HOMA model. Results All member of this family were divide into consanguinous hypertension group(group 1), consanguineous normotensive group(group 2)and affinity normatensive (group 3). There was significant difference in IR between group 1(group 2)and group 3. The logistic analysis showed that age was the major risk factor of hypertension in consanguinous group, and in affinity group the major risk factors were age and IR. Conclusions Insulin resistance provided some influence to blood pressure in members of this family, and an advanced study would be needed to explore if insulin resistance is a good intermediate phenotype for hypertension in this extended family. But insulin resistance may be a major risk factor of hypertension in a general population.
出处
《高血压杂志》
CSCD
2003年第1期54-56,共3页
Chinese Journal of Hypertension
基金
国家自然科学基金 (39870 6 5 0 )
北京市科技项目(95 5 0 2 0 6 0 0 )资助
