摘要
目的 探讨氨氯地平抗动脉粥样硬化的作用机制。方法 建立兔动脉粥样硬化模型 ,分为实验 1、2、3组、实验对照组 (AS组 )、空白对照组 ,检测各组不同时期血清中一氧化氮 (NO)、血浆中内皮素 (ET)水平。结果 血清中NO平均值 ,实验 1、2、3组、AS、空白对照组分别为 :4 .71± 0 .35 ,4 .6 2± 0 .4 8,3.71± 0 .5 6 ,2 .12± 0 .34,6 .72± 0 .37mmol/l。实验组与实验对照组比较 ,NO值明显升高 ,差异显著 (P <0 .0 1)。血浆中ET平均值 ,上述各组分别为 :30 2 .11±4 6 .2 1,2 84 .32± 37.2 5 ,35 7.79± 34.18,1835 .83± 2 6 .6 5 ,10 7.2 4± 2 4 .8Pg/ml。实验组与实验对照组比较 ,ET值明显降低 ,差异显著 (P <0 .0 1)。结论 : 氨氯地平抗动脉粥样硬化的作用机制可能与升高血清中NO、降低血浆中ET有关。
Objective To investigate the mechanism of treatment of anti atherosclerosis by amlodipine. Methods To establish rabbit model of atherosclerosis, involing the treatment groups 1,2,3 the treatment control group, the empty control group. Plasma nitric oxide (NO) and serum endothelin (ET) were measured during this experiment regularly. Results The average plasma NO in the treatment groups 1,2,3, the treatment control group, the empty control group were 4.71±0.35, 4.62±0.48, 3.71±0.56, 2.12±0.34, 6.72±0.37 mmol/l. The results of plasma NO were increased after treatment by amlodipine significantly (P<0.01). The average serum ET in those groups were 302.11±46.21, 284.32±37.25, 357.79±34.18, 1835.83±26.65, 107.24±24.8Pg/ml. The results of serum ET were decreased after treatment by amlodipine significantly (P<0.01). Conclusion Amlodipine has the effect of anti atherosclerosis. The mechanism maybe contacted with increased plasma NO and decreased serum ET.
出处
《中国实验诊断学》
2003年第1期21-22,共2页
Chinese Journal of Laboratory Diagnosis
