摘要
在 0℃下 ,以四氢呋喃为溶剂 ,用氢化铝锂还原α ,β 不饱和酯和酮 ,除得到正常的还原产物一醇外 ,还以适中的产率方便地得到 1,3 二醇 ,该反应原料易得 ,操作简单 ,有望应用于合成含有 1,3
A novel reaction of α,β-unsaturated esters and ketones with lithium aluminum hydride in dry tetrahydrofuran solution at 0 ℃ affords, in addition to saturated and unsaturated alcohols, the corresponding 1,3-diols in moderate yield. The utility of the transformation is available for staring materials. The synthetic routes are facile and the reactions can be performed on molar scales. Direct application can be expected in the synthesis of the natural products containing 1,3-diol structural unit.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2003年第2期279-284,共6页
Acta Chimica Sinica
基金
国家自然科学基金 (创新研究群体基金 2 0 0 1 .1~ 2 0 0 3.1 2 )资助项目
