摘要
酪氨酸的氨基和酚羟基经Boc和苄基保护后,氢化铝锂还原及脱保护得酪氨醇.酪氨醇在Et3N作用下与CS2反应关环得一种新的Evans试剂—4-(对羟基苄基)-噁唑-2-硫酮,总产率达46%,探讨了投料比、时间和温度对反应的影响.
Described a new kind of Evans reagent-4 - （ p -hydroxyl） -benzyl oxazolidinethione which was prepared ：by following six steps： amino protection, esterification and hydroxyl protection, reduction by Li- A1H4, deprotection, cyclization with triethylamine. Total yields were 46 % and tile factors influencing each step＇s productivity, such as the ratio of materials, time of the reaction and temperature of the reaction were investigated.
出处
《湖北大学学报（自然科学版）》
CAS
北大核心
2005年第4期369-372,共4页
Journal of Hubei University：Natural Science
基金
国家自然科学基金(No:20372019)资助项目
关键词
酪氨酸
还原
合成
嗯唑-2-硫酮
L - tyrosine
reduction
synthesis
oxazolidine - 2 - thione
