摘要
AIM:To study the relationship between prognosis and pathological characteristics,proliferating cell nuclear antigen labelin index(PCNA-LI)and DNA index(DI)in patients with moderately differentiated hepatocellular carcinorma(HCC).
AIM:To study the relationship between prognosis and pathological characteristics,proliferating cell nuclear antigen labeling index(PCNA-LI)and DNA index(DI)in patients with moderately differentiated hepatocellular carcinoma(HCC). METHODS:51 cases of moderately differentiated HCC were analyzed with respect to the relation between their clinical follow-up data and pathological characteristics.Meanwhile, PCNA-LI of HCC cells was detected by immunohistochemistry assay and DI was measured by Feulgen staining and automatic image analysis technique. RESULTS:Patients with a single tumor nodule,less than 5 cm in diameter,no tumor emboli,no daughter nodules and necrosis had relatively better prognosis;patients with euploidy HCC had better prognosis than those with aneuploidy;among the aneuploidy patients those with DI <1.5 had.better prognosis than the cases with DI>1.5;The higher the PCNA-LI,the worse would be the prognosis.The increase in DI was correlated with the increase in PCNA-LI, and both of them were correlated with the pathological changes of the tumor. CONCLUSION:A composite analysis of the pathological characteristics of tumor tissue,DI and PCNA-LI might be useful in predicting the prognosis of HCC patients.
基金
the Foundation of the Minister of Science and Technology,No 96-906-01-15
