摘要
目的 :研究p2 7蛋白在胃癌中的表达及其与临床病理学特征的关系。方法 :应用SP免疫组化法 ,对 2 0例胃良性病变标本及 62例胃癌组织p2 7的表达及其与临床病理学特征的关系进行分析。结果 :p2 7在胃良性病变中的阳性率为 10 0 % (2 0 2 0 ) ,而在胃癌中的阳性率为 4 1 9% (2 6 62 ) ,p2 7在两组织中的表达差异有显著性 (P <0 0 5 ) ;p2 7的阳性表达在未累及浆膜及淋巴结未转移者显著高于累及或穿透浆膜及有淋巴结转移者 (P <0 0 5 )。结论 :p2 7参与胃癌的进展 。
Objective To study the expression of p27 protein in gastric carcinoma and its relation to the clinicopathological features. Methods p27 protein expression in 62 cases of human gastric carcinoma and in 20 cases of stomach benign disease were examined with SP immunohistochemical staining.p27 protein expression were analysed together with its relation to clinic pathological feature Results The positive rate of p27 protein in stomach benign disease was 100%(20/20) and 41.9%(26/62) in gastric carcinoma.Its expression difference in two type tissues was no significance statistically(P<0.05).In no seromembranous involvement group and free lymph node metastatic group,the possitive expresion rate of p27 protein was higher than that in the group with seromembranous involvement or penetration and with lymph node metastasis respectively (P<0.05).Conclusion p27 participates in the progression of gastric carcinoma and may become an important prognostic factor.
出处
《肿瘤防治杂志》
2003年第2期144-145,共2页
China Journal of Cancer Prevention and Treatment
关键词
癌基因蛋白质类
生物合成
胃肿瘤
病理学
免疫组织化学
oncogene proteins/recombinant proteins
gastric neoplasms/pathology,immunohistochemistry
