摘要
目的 观察并探讨Feeney法创伤性脑损伤中大鼠神经功能及海马神经元的变化 ,以选择一种合理的大鼠脑损伤模型致伤方案。 方法 用 2 0g重棒分别从 10 ,30cm、40g重棒从2 5cm的高度打击SD大鼠一侧脑皮层致伤 ,观察伤后大鼠神经功能及海马神经元的变化。 结果2 0 0g·cm所致的损伤伤后无明显的神经功能障碍和海马结构的改变 ;6 0 0g·cm可造成一定程度的神经功能障碍及伤侧海马神经元变性坏死 ;10 0 0g·cm可引起伤后严重的神经功能缺损 ,伤侧海马结构被完全毁损。 结论 Feeney法创伤性脑损伤模型中 6 0 0g·cm打击方案是较为合理且又能致创伤性脑损伤后大鼠神经功能及海马神经元改变的脑损伤方案。
Objective To observe and explore the changes of neural behavior and hippocampal neurons of brain injured rats in Feeney traumatic brain injury model in order to choose a reasonable way inducing traumatic brain injury. Methods Feeney's traumatic brain injury model was made through striking rat's cortex by using 20 g bat dropping from height of 10 cm, 30 cm and 40 cm respectively, or 40 g bat from 25 cm. Changes of neural behavior and hippocampal neurons were observed after injury. Results Strike with 200 g·cm could not cause an obvious changes of neural behavior and hippocampal neurons. Strike with 600 g·cm brought about certain deficits of neural behavior and abnormality and necrosis of hippocampal neurons. Strike with 1 000 g·cm severely damaged neural behavior and completely destroyed the structure of ipsilateral hippocampus. Conclusions Strike with 600 g·cm in Feeney traumatic brain injury model is a reasonable way to cause traumatic brain injury with changes of neural behavior and hippocampal neurons.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2003年第4期231-234,共4页
Chinese Journal of Trauma
基金
交通部科技进步"通达计划"基金资助项目 ( 95 -0 6 -0 2 -31)
关键词
脑损伤
大鼠
神经功能
海马
神经元
Brain injuries
Neuronal function
Hippocampus
Models
