摘要
目的观察纳络酮对血浆内皮素、血液流变学及海马神经原坏死的影响。方法通过大鼠脑损伤模型，测定血浆和海马内皮素、血液流变学指标及海马神经原坏死数。结果脑损伤组血浆、海马内皮素水平、全血粘度、红细胞聚集指数、血浆纤维蛋白原含量及Ｃａｓｓｏｎ屈服值均明显升高，海马神经原坏死数也明显增加；经纳络酮治疗后上述指标均明显下降，海马神经原坏死数也明显减少。结论纳络酮可通过改善血液流变学特性和降低内皮素水平来保护海马神经原，并对继发性脑损害起到治疗作用。
bjective To observe the effects of naloxone on levels of ET1 hemorheological properties and death of hippocampal neuron after brain trauma.Methods The levels of ET1 in the plasma and hippocampus of rat with brain trauma were determined by RIA,hemorheological properties of rats following brain injury were studied. Results Levels of ET1 in the plasma and hippocampus of rat with brain trauma and death of hippocampal neuron increased significantly,but decreased markedly after administration of naloxone.As compared with brain injury group,the blood viscosities,erythrocyte aggregation index,fibrinogen levels,and Casson yielding value were decreaased significantly in the rats with naloxone treatment after injury.Conclusion:ET1 may play some important roles in causing death of hippocampal neuron after brain trauma,and naloxone can protect hippocampal neuron by decreasing levels of ET1 and improving hemorheotogical situation
出处
《温州医学院学报》
CAS
1998年第2期98-100,共3页
Journal of Wenzhou Medical College
关键词
脑损伤
海马
内皮素
血液流变学
纳络酮
Brain trauma Endothelin(ET1) Hippocampus Hemorheologe Naloxone
