摘要
为探讨血清嗜酸粒细胞阳离子蛋白 ( ECP)和免疫球蛋白 E( Ig E)水平在哮喘病中的意义 ,对 75例哮喘患儿和 2 0例健康儿进行了 ECP及 Ig E检测。结果哮喘发作期 ( 2 8例 )、ECP水平显著高于稳定期 ( 2 3例 )、缓解期 ( 2 4例 )及健康儿 ,稳定期、缓解期 P均 <0 .0 1;Ig E则发作期高于缓解期和健康儿 ( P<0 .0 1) ,但与稳定期无差异 ( P>0 .0 5 )。认为血清 ECP水平能更准确地反映嗜酸粒细胞的活化状态和气道炎症变化 ,且较 Ig E敏感 ,是诊断哮喘。
To investigate the significance of serum eosinophil cationic protein (ECP) and immunoglobuline E (IgE) in asthma, ECP and IgE of 75 children with asthma and 20 heathy children as control were detected. ECP was examined by the immuno-CAP system and IgE was examined by enzyme linked immunosorbent assay (ELISA). Results showed that the concentration of serum ECP of asthmatic children in paroxysmal phase was obviously higher than that in stable and alleviated phases and the control group. The concentration of IgE of asthmatic children in paroxysmal phase was significantly higher than that in alleviated phase and the control group but had no difference with that in stable phase(P>0.05). There was no much relationship between serum ECP and IgE (P>0.05). These suggest that the level of serum ECP can reflect the inflammation in the bronchial tube and the activated state of eosincyte more sensitively than IgE.
出处
《山东医药》
CAS
北大核心
2003年第7期13-14,共2页
Shandong Medical Journal
