摘要
目的:分析孟鲁司特钠与布地奈德对毛细支气管炎患儿血清嗜酸粒细胞阳离子蛋白(ECP)、白细胞介素-8(IL-8)的影响,比较二者对毛细支气管炎的疗效。方法:选取我院确诊的毛细支气管炎患儿100例,随机分为A组(孟鲁司特钠口服)和B组(布地奈德雾化)各50例,监测孟鲁司特钠和布地奈德干预前后血清ECP、IL-8水平,并随访治疗后1年的复发情况。结果:A组ECP浓度从干预前(19.15±13.34)μg/L降至干预后(9.58±5.21)μg/L,B组ECP浓度从干预前(20.47±12.21)μg/L降至干预后(5.15±4.01)μg/L。干预前两组ECP比较差异无统计学意义(t=1.002,P>0.05);干预后A组ECP显著低于B组,两组比较差异有统计学意义(t=3.396,P<0.01)。干预后两组IL-8均明显下降,但组间比较差异无统计学意义(干预前t=1.479,干预后t=0.187,P均>0.05)。结论:A组治疗后患儿血清ECP下降更明显,复发率更少,说明孟鲁司特钠比布地奈德能更有效地治疗毛细支气管炎。
Objective： To analyze the efficacy of patients with bronchiolitis through the comparison of the concentrations of serum eosinophils cationic protein （ECP）, interleukin-8 （IL-8） and clinical outcomes before and after the use of montelukast and budesonide. Methods ： One hundred infants with bronchiolitis in the First Affiliated Hospital of Fuzhou were enrolled in the present study. After the conventional therapy, they were randomly divided into group A （50 cases） with oral intake montelukast and group B （50 eases） with inhaling budesonide. The concentrations of ECP and IL-8, were monitored before and after the intervention therapy. Clinical manifestations of the two groups in one-year follow-up were recorded respectively. Results ： After intervention, the ECP concentration of group A was decreased from （19.15±13.34） μg/L to （9.58±5.21） μg/L; that of group B was also decreased from （20.47±12.21） μg/L to （5. 15±4. 01 ） μg/L. Before medication intervention, the difference of ECP between the two groups was not statistically significant （t = 1. 002, P〉0.05）. But after intervention, ECP concentration of group A was significantly lower than that of group B. The difference was statistically significant （t = 3. 396, P〈0.01 ）. Although IL-8 concentration of the group A and B decreased significantly after intervention, the difference between the two groups was not significant before and after the intervention （before intervention： t = 1. 479, P〉0.05; after intervention： t = 0. 187, P〉0.05）. Conclusions： In group A, serum ECP significantly decreased, and the recurrence rate was lower than that in group B. It demonstrated that montelukast could effective to airway inflammation in hronchiolitis.
出处
《儿科药学杂志》
CAS
2012年第10期9-11,共3页
Journal of Pediatric Pharmacy
