摘要
目的 :探讨T淋巴细胞表面分子CD4 、CD2 8在特发性血小板减少性紫癜 (ITP)的变化。方法 :用流式细胞术检测 2 1例ITP患者和 9例正常对照外周血淋巴细胞CD+4、CD+2 8、CD+4CD+2 8的表达率以及CD+4T淋巴细胞中的CD+2 8表达率。结果 :ITP患者外周血CD+4、CD+2 8、CD+4CD+2 8表达明显低于正常对照 ,但CD4 细胞中CD+2 8表达与正常对照相比无显著差异。ITP患者外周血淋巴细胞中的CD+2 8表达率与CD+4表达率呈正相关。结论 :ITP患者CD+4T淋巴细胞减少并非因协同刺激信号分子CD2 8表达下降所致 ,CD+4T淋巴细胞无协同刺激信号分子CD2
Objective: To investigate the change of T lymphocyte surface molecules CD 4 and CD 28 expressions in peripheral monoculear cells in patients with idiopathic thrombocytopenic purpura(ITP). Methods: The expressions of CD + 4,CD + 28 ,CD + 4CD + 28 of peripheral lymphocytes and the expression of CD 28 in CD 4 T lymphocytes were measured by flow cytometry in 21 ITP patients and 9 normal controls. Results: The expression of CD + 4,CD + 28 , CD + 4CD + 28 were lower in ITP patients than that in normal controls. Nevertheless,CD 28 expression in CD 4 cells was normal. Marked correlation was found between CD + 4 expression and CD + 28 expression. Conclusion: In ITP patients,decreasing expression of CD + 4T lymphocytes may not result from Decreasing expression of costimulator CD + 28 . There is no deficiency in expression of CD 28 in CD 4 T lymphocytes in ITP patients.
出处
《武汉大学学报（医学版）》
CAS
2003年第2期121-123,139,共4页
Medical Journal of Wuhan University
