摘要
目的 :探讨肝细胞生长因子 (HGF)与妊娠高血压综合征 (妊高征 )发病的相关性。方法 :采用逆转录 -聚合酶链式反应 (RT PCR)检测 2 0例重度妊高征患者 (妊高征组 )胎盘组织中HGFmRNA表达水平 ,并以 2 0例健康孕妇 (对照组 )为对照。结果 :妊高征组胎盘组织HGFmRNA表达峰度为 0 .19± 0 .0 7,较对照组 ( 0 .3 3± 0 .0 5 )显著降低 (P <0 .0 5 )。结论 :妊高征患者HGF表达异常发生于转录水平 。
Objective:To determine whether pregnancy induced hypertension (PIH)is associated with hepatocyte growth factor(HGF).Methods: The expression of HGFmRNA in the placenta from 20 PIH patients and 20 normal blood pressure controls was assessed by reverse transcriptional-polymerase chain reaction(RT-PCR).Results: The transcription of HGFmRNA in the placenta from PIH group decreased significantly(P<0.05).Conclusions: The result suggested that the abnormal expression of HGF in PIH occurred in post-transcription levels.It was considered that the abnormal expression of HGF may play an important role in the pathogenesis of placental ischemia in PIH.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2003年第2期105-106,共2页
Journal of Practical Obstetrics and Gynecology
关键词
妊娠高血压综合征
肝细胞生长因子
胎盘
Pregnancy induced hypertension
Hepatocyte growth factor
Placenta
