摘要
目的 :探讨甘草多糖对于S 180荷瘤小鼠体内肿瘤的抑制作用及其机制。方法 :Balb/c小鼠接种S 180肉瘤瘤株后 ,分别给予甘草多糖和对照药物 12天 ,然后处死。将荷瘤小鼠的肿瘤取出称重 ,并进行比较 ;免疫组织化学方法和HE染色对肿瘤中的bcl 2、p5 3和bax蛋白进行比较分析。结果 :给予甘草多糖的小鼠的肿瘤明显小于对照组 ,而对照组的bcl 2和 p5 3蛋白的表达率明显高于甘草多糖的小鼠组 ,bax蛋白的表达率则低于后者。 结论 :甘草多糖对于小鼠S 180肿瘤具有抑制作用 ,并有可能影响bcl 2、p5 3及bax基因蛋白的表达。
Objective:To investigate the anti tumor effect of the Glycyrrhizia polysaccharide (GPS) and its mechanism.Methods:The S 180 tumor from mice was collected and the anti tumor rate calculated. The expression of Bax,Bcl 2 and P53 protein in the tumor tissue was studied by immuno histochemistry method.Results:The tumor of the B,C and D group was lighter than that of A group. The expression frequency of Bax,Bcl 2 and P53 protein differed significantly among the groups.Conclusion:The GPS can resist the mouse tumor, and it might be affect the expression of the Bax? Bcl-2 and P53.
出处
《临床肿瘤学杂志》
CAS
2003年第2期85-87,共3页
Chinese Clinical Oncology
