摘要
Objective To investigate the significance of p27 expression in colorectal carcinomas(CRCsa).Methods The samples were obtained from 44 cases.P27 expression was detected by immunohistochemisty using the SABC staining method at the three sites:carcinoma tissue,pericarcinoma(1 cm away from CRC)and the incision margin(3 cm away from CRC).Results Expression of p27 was found in 56.82%(25/44)of CRCs,in 88.64%(39/44) of percarcinoma and and in 97.73%(43/44)of the mucosa at the incison margin.P27 expression in CRCs was correlated significantly with Dukes stage(P<0.05), histology grade(P<0.01)and local lymph node involvement(P<0.05),but not with age,gender,and site or size of the CRC.Conclusion The decrease of p27 expression may be involoved in the malignant transformation of colorectal epithelial cells to CRC.Expression of p27 in CRC correlates with some clinicopathological characteristices and may be of prognostic significance.
