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透明质酸与肿瘤淋巴转移的相互关系 被引量:3

The relationship between hyaluronan and tumor lymphatic metastasis
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摘要 HA是细胞外基质的主要成分之一。组织中的大部分HA经淋巴管运输 ,并在淋巴结内被巨噬细胞和内皮细胞摄取和降解。肿瘤细胞或受肿瘤细胞刺激的细胞产生大量的HA。HA受体介导HA对肿瘤细胞的附着、增殖和迁移的作用。肿瘤细胞自淋巴管向淋巴结转移依赖于HA的存在。HA激活淋巴结内的巨噬细胞 ,从而抑制肿瘤淋巴转移。
出处 《解剖科学进展》 CAS 2003年第1期67-71,共5页 Progress of Anatomical Sciences
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