摘要
目的 :探讨头穴透刺对急性脑梗塞大鼠脑组织中 β EP(β Endorphin ,β内啡肽 )与cAMP(cyclicAMP ,环磷腺苷 )含量变化的相关性。方法 :用线栓法直接阻断大鼠大脑中动脉开口处制作急性脑梗塞模型 ,采用放免技术 ,检测头穴透刺对急性脑梗塞大鼠脑组织中 β EP与cAMP含量的影响。结果 :头穴透刺后可使大鼠脑组织中cAMP的含量明显升高 ,使 β EP含量明显降低而趋于正常值 ,两者之间呈显著负相关。结论 :头穴透刺可以调节脑组织中 β EP与cAMP的含量 ,改善梗死脑组织供血 ,这可能是针灸发挥治疗作用的重要机制之一。
Objective To research the correlation of scalp-point penetration needling with the content of β-EP and cAMP in the brain tissue of rats with acute cerebral infarction.Methods acute cerebral infarction was produced by blocking blood flow of the middle cerebral artery.After acupuncture,the content of β-EP and cAMP in the brain tissue of rats was observed with radio-immunoassay (RIA).Results After acupuncture,the content of cAMP increased significantly and the content of β-EP lowered evidently and was close to that of normal group.There was significant negative correlation between the content of β-EP and cAMP.Conclusion Scalp-point penetration method can adjust the content of β-EP and cAMP in the brain tissue of rats with acute cerebral infarction and improve the focus of infarct's blood suppls blood supply,w of the important mechanisms of acupuncture treatment.
出处
《中国中医基础医学杂志》
CAS
CSCD
2003年第1期47-49,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
湖北省科委重点科技项目 ( 971P14 0 1)
关键词
脑梗塞
头针
透刺
Β-EP
CAMP
Cerebral infarction
Scalp-acupuncture
Point-through-point acupuncture
β-EP cAMP
