摘要
目的 观察非痴呆中老年人海马区阿尔茨海默痴呆样病理改变的基本情况 ,探讨老年痴呆样病理改变与年龄、性别及互相之间的关系。 方法 选择病史中无老年性痴呆 (AD)及精神异常记录的全身尸检病例 13 8例为研究对象 ,在外侧膝状体平面取双侧海马 ,经固定、切片后 ,分别进行HE、硝酸银染色。应用图像分析仪分别记录老年斑、神经原纤维缠结、平野小体、颗粒空泡变性在海马区的分布情况 ,主要统计分析CA1区老年斑、神经原纤维缠结、平野小体、颗粒空泡变性的密度 (个/mm2 )、出现率与年龄和性别及互相之间的关系。 结果 (1)老年斑、神经原纤维缠结、平野小体、颗粒空泡变性主要分布在海马CA1区 ,CA2区只见到神经原纤维缠结 ,CA3区可出现老年斑、神经原纤维缠结。 (2 )海马CA1区老年斑、神经原纤维缠结、平野小体、颗粒空泡变性的密度 (个 /mm2 )、出现率与年龄密切相关 ,与性别无关 ,各种AD样病理改变间的出现率和数量互相关联。 结论 (1)老年斑、神经原纤维缠结、平野小体、颗粒空泡变性主要分布在海马CA1区 ,CA2、CA3区少见。 (2 )海马CA1区AD样病理改变与年龄密切相关 ,与性别无关 ;(3 )
Objective To study the relationship among Alzheimer-like neuropathologic changes and their relationship with age and sex. Methods From January 1,1986 to April 1,2000,all autopsy caus of non-demented individuals ≥40 years of age in the General Hospital of PLA were examined for Alzheimer-like neuropathologic changes in hippocampus.There were 41 female and 97 male. Senile plaques(SP),neurofibrillary tangles(NFT) were identified with modified Palmgren-stain method. Hirano bodies(HB) or granulovacuolar degeneration(GVD) were identified with HE stain methods. Results About 40% patients had Alzheimer-like neuropathological changes in hippocampus. There was a highly significant correlation was found between the incidence and severity of SP?NFT?Hirano or GVD and patients' age in the CA1 field of the hippocampus, but no significant difference between male and female. There was a strong correlation among the prevalence and numerical densities of these four types of Alzheimer-like changes. Conclusions Alzheimer-like neuropathologic changes were mainly distributed in CA1 of hippocampus. In CA1 they had relationship with age, but no relationship with sex and they had correlation each other.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2003年第3期153-155,共3页
Chinese Journal of Geriatrics
