摘要
目的 探讨血浆内毒素在急、慢性肝炎和肝硬化患者的表现。方法 对慢性乙型肝炎患者 3 71例 ,急性甲型或戊型肝炎患者 79例和正常健康人 5 0例 ,用偶氮显色法检测血浆内毒素水平。绘制ROC曲线对肝炎患者数据的三分位进行分析 ,观察在急性肝炎、不同慢性肝炎和肝硬化患者间血浆内毒素水平的差异。结果 急性甲型或戊型肝炎、慢性乙型肝炎中度、重度及其肝硬化患者血浆内毒素水平较正常对照组、慢性乙型肝炎轻度水平显著增高 ,随病情发展 ,明显上升。相互间可以寻找判断限 ,予以区分。而且 ,所有肝炎患者内毒素结果以百分位数排列 ,用三分位观察时 ,有较好的差别。结论 对肝炎患者进行血浆内毒素测定 。
Objective To investigate the plasma endotoxin levels in patients with acute, chronic hepatitis and liver cirrhosis. Methods Quantiative determination of the endotoxin levels in plasma of 371 patients with chronic hepatitis, 79 patients with acute hepatitis A or E, and 50 healthy adults. All the results were analysed with ROC curve to select some cut-off points among different patients and healthy adults, and the patient results were also dealt with tertiles analysis. Results The plasma endotoxin levels in patients with acute hepatitis A or E, patients with chronic hepatitis B and patients with liver cirrhosis were significantly higher than healthy people and patients with light chronic hepatitis B. The endotoxin levels were likely to follow the clinical setting condition of hepatitis stage. The selected cut-off points of endotocxin levels seemed to be useful to distinguish the disease stage among the hepatitis patients. All the patient's plasma endotoxin levels arranged in percentile, The tertiles analysis showed that the endotoxin levels in hepatitis patients were useful index for differentiation of disease stage. Conclusion The plasma endotoxin levels in patients with hepatitis could provide useful information for clinical medicine.
出处
《上海医学检验杂志》
北大核心
2003年第2期87-89,共3页
Shanghai Journal of Medical Laboratory Sciences
