摘要
目的 :考察 (2 5± 5 )℃下 ,注射用阿昔洛韦与头孢拉定在 0 .9%氯化钠注射液 (NS)中的配伍稳定性。方法 :采用反相高效液相色谱法测定注射用阿昔洛韦与头孢拉定在NS中配伍 18h内各时间段的含量、pH值及微粒数 ,同时观察外观性状变化。结果 :两药配伍后 8h内含量均在 98%以上 ,18h时 ,两药含量略有下降 ,外观颜色略显微黄 ,pH值、微粒数无明显改变。结论
Objective:To examine the stability of compatibility of aciclovir sodium for injection and cefradine in normal saline(NS) at 25±5℃. Methods:Reversed phase high performance liquid chromatography method was used to determine the contents of aciclovir sodium and cefradine in NS at various time periods within 18 h. The outward character of the solution was kept under observatien and the pH and number of particles were determined. Results:When aciclovir sodium and cefradine were mixed in NS for less than 8 h, the contents of both drugs were higher than 98%. However, at the 18 th h, the contents of the two drugs were slightly reduced, and the colour of the solution turned light yellow. No obvious changes were found in pH and number of particles. Conclusion:Aaciclovir sodium for injection and cefradine were shown to be compatible within 8 h when mixed in NS.
出处
《医药导报》
CAS
2003年第4期272-274,共3页
Herald of Medicine
关键词
阿昔洛韦
头孢拉定
配伍
稳定性
高效液相色谱法
Aciclovir
Cefradine
Compatibility
Stability
High performance liquid chromatography
