摘要
目的 :评价阿奇霉素治疗小儿支原体肺炎的临床疗效和安全性。方法 :支原体肺炎患儿 80例 ,随机分为治疗组和对照组各 40例 ,进行单盲对照试验 ,治疗组给予注射用阿奇霉素 10mg·kg 1 ·d 1 ,用 0 .9%氯化钠注射液稀释为 1～ 2mg·mL 1 ,分 2次 ,q 12h ,静脉滴注 ,每次滴注时间不少于 60min ,3～ 7d后改为阿奇霉素口服 ;对照组用红霉素 15～ 3 0mg·kg 1 ·d 1 ,用 10 %葡萄糖注射液或 0 .9%氯化钠注射液稀释为 1mg·mL 1 ,静脉滴注。两组均以治疗 7～ 10d为 1个疗程。结果 :治疗组和对照组的 3d显效率分别为 72 .5 % ,3 7.5 % ;7d治愈率分别为 5 0 .0 % ,2 3 .7% ;10d治愈率分别为95 .0 % ,77.5 % ;不良反应发生率分别为 10 .0 % ,3 0 .0 % ,并且对照组 2例因严重不良反应而停药。结论 :与红霉素相比 ,阿奇霉素治疗小儿支原体肺炎具有疗效高、不良反应发生率低、起效快等优点。
Objective:To evaluate the clinical therapeutic effectiveness and safety rate of azithromycin in the treatment of mycoplasmal pneumonia in children. Methods:80 patients with mycoplasmal pneumonia were randomly divided into 2 equal groups with 40 children each. The study was carried out with the mono blind method. Patients of the treatment group were given each a daily dose of 10 mg·kg 1 of azithromycin which was diluted to a concentration of 1～2 mg·mL 1 with 0.9% sodium chloride solution and administered by IV instillation q 12 h. Each instillation lasted no less than 60 min. 3～7 days later azithromycin was given PO. Patients of the control group were given each a daily dose of 15～30 mg·kg 1 of erythromycin diluted with 10% glucose solution or 0.9% sodium chloride solution to a concentration of 1 mg·mL 1 and administered by IV instillation. The course of treatment in both groups lasted 7～10 days. Results:The rates of excellent therapeutic effectiveness on day 3 were 72.5% and 37.5% in patients of the treatment group and control group, respectively. The cure rates on day 7 were 50.0% and 23.7%, while those on day 10 were 95.0% and 77.5% in patients of the treatment group and control group, respectively. The incidences of adverse reactions were 10% and 30% in patients of the treatment group and control group, respectively. Erythromycin was discontinued in 2 patients of the control group owing to severe adverse reactions. Conclusion:Azithromycin was shown to have the advantages of quick action, high curative effect and low incidence of adverse reactions in the treatment of childhood mycoplasmal pneumnonia as comparel with erythromycin.
出处
《医药导报》
CAS
2003年第4期251-252,共2页
Herald of Medicine
关键词
阿奇霉素
红霉素
肺炎
支原体
Azithromycin
Erythomycin
Pneumonia, mycoplasmal
