摘要
[目的]为美国中医诊所中西医结合促排卵治疗寻求一种非损伤性的孕酮评估方法。[方法]不孕妇女42例随机分为克罗米酚(CC)治疗组、绝经期妇女尿促性腺激素(HMG)治疗组和中西医结合(CC+TCM)治疗组。治疗后以放射免疫法测定促排卵周期之黄体期及正常妇女21例配对血清及唾液标本的孕酮浓度。[结果]治疗组之黄体期唾液孕酮值范围为(294.0±31.0)pg/mL至(499.0±75.0)pg/mL,与正常月经周期组之孕酮值非常接近;而治疗组中配对之血清孕酮范围则是(28.6±4.2)ng/mL至(51.4±16.6)ng/mL。治疗后各治疗组妊娠妇女的唾液与血清孕酮含量较非孕妇女高(P<0.05);血清与唾液孕酮值呈正相关关系。不孕妇女治疗后的妊娠率CC+TCM组为46.7％,CC组为42.9％,HMG组为46.0％,3组总妊娠率比较差异无显著性(p>0.05)。[结论]测定唾液孕酮浓度,是一种替代检测血清孕酮的实用、有效而简便的评估方法;中医中药在促排卵治疗中的效果与CC和HMG相仿。
[Objective] To search a noninjurious detecting method of progestin level for the evaluation of TCM combined with western medicine for infertility with ovarian dysfunction. [ Methods] Forty - two cases of infertility were treated with clomiphene citrate (CC), human menopausal gonadotropins (HMG) and CC combined with TCM respectively. Progestin levels in saliva and serum of the above cases in luteal phase were detected by radioimmunoassay method and were compared with those in 21 normal women. [Results] Saliva progestin level in luteal phase of the three treatment groups ranged from (294.0?1.5) pg/mL to (499.0 + 75.0) pg/mL, which was similar to that of the normal volunteers. And the matched serum progestin level in luteal phase of the three treatment groups ranged from (28.6 ?4.6) ng/mL to (51.4 ?16.6) ng/mL. After treatment, progestin levels in saliva and serum of pregnant cases in the treatment groups were higher than those of unpregnant, progestin levels in saliva and serum of pregnant cases in the treatment groups were higher than those of unpregnant cases ( P < 0.05); a positive correlation was found between saliva progestin level and serum progestin level. Pregnant rate in CC + TCM group, CC group and HMG group were 46.7% , 42.9% and 46.0% respectively, the differences being not significant (P > 0.05). [Conclusion] Detecting method of saliva progestin level is practical, effective and convenient and can be used as an alternative of serum progestin level detection. The effect of TCM is similar to that of CC and HMG.
出处
《广州中医药大学学报》
CAS
2003年第1期35-39,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
孕酮
血液
唾液分析
不育
女(雌)性
中西医结合疗法
针灸疗法
毓麟珠
中极穴
子宫穴
PROGESTERONE/blood
SALTVA/analysis
INFERTILIIY, FEMALE/TCM - WM therapy
INFERTILITY, FEMALE/acup - mox therapy
YULINZHU/ther. use
POINT GV3 (ZHONGJI)
POINT EX-CA1 (ZIGONG)
