摘要
目的 :探讨功能性不良 (FD)患者的抑郁障碍及抗抑郁药对其疗效。方法 :以CCMD -2 -R为标准诊断抑郁障碍。将伴抑郁的FD随机分为 3组 :文拉法新组、多塞平组和对照组 (常规内科治疗 )。以治疗前、治疗 2周和 8周FD症状积分及Zung抑郁自评量表 (SDS)积分变化评定疗效。结果 :( 1)FD中抑郁障碍的发生率为 3 2 2 8% ;( 2 )FD症状积分在文拉法新组和多塞平组于治疗 2周时即明显减少 (P <0 0 5 ) ,于治疗 8周时非常明显低于对照组 (P <0 0 1) ;SDS积分在文拉法新组于治疗 2周时即明显减少 (P<0 0 5 ) ,文拉法新组和多塞平组于治疗 8周时均明显低于对照组 (P <0 0 5 ) ;( 3 )文拉法新组不良反应明显低于多塞平组。结论 :FD伴发的抑郁障碍发生率高 ,抗抑郁治疗能有效改善消化不良和抑郁症状 ,文拉法新作用迅速且优于多塞平。
Objective: To investigate the rate of depression in patients with functional dyspepsia (FD) and corresponding treatments Method:285 out-patients diagnosed as FD were assessed by two physician trained for depression assessment Depression was diagnosed by criteria of CCMD-2-R Patients with depression were divided into three groups: group A (n=28) received venlafaxine, group B (n=31) received doxepine, group C (n=26) received no antidepressant as control SDS (self-rate depression scale) and FD score were used to assess the effect of antidepressants Result:The rate of depression in our sample was 32% (92/285) Among 92 with depression, 85 consent to participate the study FD scores of both group A and group B decreased after 2 weeks treatment, and were significantly lower than that of group C at the end of 8 weeks The score of SDS in group decreased from the end of second week after treatment, and both group A and group B had significantly lower scores in SDS than group C at the end of 8 weeks Group A had fewer side effects than group B Conclusion:Depression is common in patients with FD Antidepressant can improve FD symptoms as well as depressive symptoms Venlafaxine has fewer side effects than doxepine
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2003年第3期157-158,共2页
Chinese Mental Health Journal
