摘要
目的探讨肝硬化腹水病人行门静脉腔静脉分流术前后血中血管紧张素转换酶(ACE)水平的变化。方法应用光度比色分析法对16例肝硬化合并少量腹水病人行门静脉腔静脉分流术和16例胃肠道肿瘤病人行肿瘤切除手术前后的门静脉、外周静脉和动脉血中 ACE 及门静脉压(PVP)进行了测定。结果 (1)肝硬化组术前肝静脉楔入压和术中门静脉压(PVP)显著高于术后3天和术后7天(P<0.01),对照组术中、术后3天、术后7天的 PVP 比较,三者间差异无统计学意义(P>0.05)。(2)肝硬化组术前、术中、术后3天、术后7天,动脉、周围静脉、门静脉血中的 ACZ 水平明显高于相应的对照组(P<0.01)。(3)肝硬化组术后3天、术后7天,动脉、周围静脉和门静脉血中 ACE 水平显著低于术前和术中(P<0.01)。(4)对照组之间 ACE 水平差异无统计学意义(P>0.05)。(5)肝硬化组门静脉血中 ACE 水平与 PVP 成明显正相关(r=0.48,P<0.01)。结论肝硬化腹水病人行门静脉腔静脉分流术后血浆中ACE 水平明显下降。
Objective To investigate the changes of serum angiotensin I coverting enzyme (ACE) activity in cirrhot- ic patients undergoing portacaval shunt.Method Serum ACE levels in portal vein,artery,peripheral vein were measured in 16 cirrhotic patients with ascites pre-,and after portocaval shunts and in 16 gastroenterie carcinoma cases as controls by light colorimetric analysis.Results Serum ACE levels were significantly higher before the shunt than after the shunt (P<0.01).After the shunt portal venous pressure (PVP) significantly decreased (P <0.01).Serum ACE levels were significantly higher in cirrhotic patients than in the controls (P<0.01).The PVP was in positive correlation to the levels of serum ACE in portal venous blood in cirrhotic patients (r= 0.48,P<0.001).Conclusion The levels of serum ACE decreased significantly in cirrhotic patients with por- tal hypertension after portacaval shunt.
出处
《中华普通外科杂志》
CSCD
1998年第2期96-98,共3页
Chinese Journal of General Surgery
