摘要
以快速成型、三维重构和生物学技术为基础 ,建立了新型人工生物活性骨工程化制造系统 .该系统制作的人工骨外形与被替代骨一样 ,内部都具有模拟真实骨组织微管系统的三维网架结构 ,可通过骨生长因子和活体细胞的复合 ,使其具有生物活性 ,因此弥补了传统生物填充材料由于缺乏活性而无法实现骨诱导的缺陷 .动物实验的结果表明 ,所制造的内部仿真结构 ,为人工骨的快速活化和新生骨细胞的三维并行生长提供了理想的空间条件 ,其中骨引导和骨诱导的双重机制可有效地加速骨组织的生长 。
A fabrication system for artificial bioactive bone is established based on rapid prototyping, 3D reconstruction and biological technology. The artificial bone constructed from this system possesses an external form exactly coincident with the replaced bone and an internal 3D scaffold which has the microvaso structure of natural bone tissue. Through adding the bone growth factor and viable cells into the 3D scaffold, the artificial bone can obtain bioactivity itself. This approach can improve the traditional method that could not realize osteoinduction for lack of bioactivity. The animal experimental results show that the simulated inter-structure should provides the artificial bone with a proper space for the 3D growth of the osteocyte and quick activation. Exciting both osteocondution and osteoinduction can speeds up the bone growth. The fine biological behaviors of the artificial bone are confirmed.
出处
《西安交通大学学报》
EI
CAS
CSCD
北大核心
2003年第3期273-276,共4页
Journal of Xi'an Jiaotong University
基金
国家自然科学基金资助项目 (5 9975 0 74)
