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大鼠局灶性脑缺血再灌注损伤中nNOS的表达 被引量：2

The Expression of nNOS in Brain of Rats with Focal Cerebral Ischemia Reperfusion Injury
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摘要 目的研究局灶性脑缺血再灌注损伤中神经元型NOS(nNOS)在不同脑区的表达。方法用改良的血管内栓线技术制造大鼠局灶性脑缺血与再灌注模型,应用免疫组织化学技术检测脑组织中nNOS的表达。结果①脑缺血再灌注损伤后,脑组织中nNOS的表达显著性增强,与正常对照组比较,P<0.05;②缺血侧在皮质、CA1区和CA3区的nNOS表达比对照侧显著性增强(P<0.05)。结论一侧脑缺血再灌注后,也会引起对侧损伤,但缺血侧损伤更为严重。 Objective To study the expression of neuron nitric oxide synthase （nNOS） in different brain tissue in rats with focal cerebral ischemia reperfusion injury. Methods Modified intravascular embolism method was employed to make focal ischemia in rats. Immunohistochemical method was used to detect the expression of nNOS in brain. Results ①Compared with the normal group,the expression of nNOS had remarkably enhanced after cerebral ischemia reperfusion（P〈0.05） ;②The nNOS expression in ischemia side was more obvious than opposite side in cortex,CA1 and CA3（ P〈0. 05）. Conclusion Cerebral ischemia reperfusion injury in one side can lead to damage in another side, but the former is more serious.
作者 陈世新 侯健
机构地区 咸宁学院生物医学工程系
出处 《咸宁学院学报（医学版）》 2005年第5期382-384,共3页 Journal of Xianning Univarsity(medical Sciences)
关键词 缺血再灌注 一氧化氮合酶 大鼠 Ischemia reperfusion Nitric oxide synthase Rat
分类号 R361.4 [医药卫生—病理学]
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参考文献7

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同被引文献25

  • 1梁辉,范金英,周盛年,朱海波,郭成浩,李强.大鼠局灶性脑缺血再灌注后NMDAR_1蛋白表达对神经功能恢复的意义[J].中国临床康复,2004,8(34):7688-7689. 被引量：5
  • 2王华仁,李积胜,陈俊,张珩.锌对急性缺氧小鼠海马NOS和nNOS水平的影响[J].中国应用生理学杂志,2006,22(4):395-398. 被引量：3
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  • 4PAPUCCI L,SCHIAVONE N,WITORT E,et al.Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property[J].J Biol Chem,2003,278(30):28220-28228.
  • 5DOONAN F,DONOBVAN M,COTTER T G.Activation of multiple pathways during photoreceptor apoptosis in the rd mouse[J].Invest Ophthalmol Vis Sci,2005,46(10):3530-3538.
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  • 7YEH C H,LIN Y M,WU Y C,et al.Nitric oxide attenuates cardiomyocytic apoptosis via diminished mitochondrial complex I up-regulation from cardiac ischemia-reperfusion injury under cardiopulmonary bypass[J].J Thorac Cardiovasc Surq,2004,128(2):180-188.
  • 8DHAKSHINAMOORTHY S,PORTER A G.Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells[J].J Biol Chem,2004,179(19):20096-20107.
  • 9CUONG D V,KIM N,YOUM J B,et al.Nitric oxide-cGMP-protein kinase G signaling pathway induces anoxic preconditioning through activation of ATP-sensitive K+ channels in rat hearts[J].Am J Physiol Heart Circ Physiol,2006,290(5):H1808-1817.
  • 10RAMEAU G A,CHIU L Y,ZIFF E B.NMDA receptor regulation of nNOS phosphorylation and induction of neuron death[J].Neurobiol Aging,2003,24(8):1123-1133.

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咸宁学院学报（医学版）
2005年 第5期

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