摘要
目的 探讨围手术期应用乌司他丁对胃癌根治术后患者免疫功能的影响。方法 将行胃癌根治术的患者随机分为实验组 (n =2 3 )和对照组 (n =2 3 )。实验组于术前 1天和术后第 1、3、5和 7天 ,每天给予 2 0万单位乌司他丁 (UTI)静脉注射 ;对照组不应用乌司他丁 ,予以等量生理盐水注射。 2组患者均于术前 1天和术后第 1、3、5、7天采血 ,检测T细胞亚群及白介素 -2 (IL 2 )和NK细胞活性的变化。结果 胃癌患者术前均有不同程度的免疫功能低下 ,术后第 1天CD+ 4 细胞数量、CD+ 4 /CD+ 8比值、IL-2水平和NK细胞活性均较术前显著下降 (P <0 .0 5 ) ,术后第 7天试验组上述指标迅速恢复 ,并超过术前水平 ,与对照组比较有显著性差异 (P <0 .0 5 )。结论 UTI可明显减轻胃癌患者围手术期细胞免疫抑制程度 。
Objective To evaluate the effects of perioperative administration of UTI on the immune function of gastric cancer patients underwent radical operation.Methods Forty six patients were randomly divided into UTI group( n =23),and control group( n =23).In UTI group,0.2 MU of UTI was administered daily,on the day preoperation and the day 1,day 3,day 5 and day 7 post operation.T lymphocyte subsets,IL 2 and NK cell activity in patients of both groups were assayed on preoperative day1,postoperative day 1,day 3,day 5 and day 7.Results The immune function of patients with gastric cancer was depressed at different levels before operation.On postoperative day 1,CD + 4,CD + 4/CD + 8 ratio,IL 2 and NK cell activity decreased more significantly than that on preoperation( P <0.05).The immune function recovered rapidly and exceeded the previous level in experimental group on the day 7 after operation.The difference was significant between experimental group and control group( P <0.05).Conclusion UTI significantly alleviated the negative immune reaction perioperatively in gastric cancer patients,and enhanced cell immune function.
出处
《实用癌症杂志》
2003年第1期71-73,共3页
The Practical Journal of Cancer
关键词
乌司他丁
胃肿瘤
免疫功能
Urinary trypsin inhibitor(UTI)
Gastric neoplasm
Immune function
