摘要
目的：探讨早期肠内营养对胃肠癌患者术后 T淋巴细胞免疫功能的影响。方法： 45例胃肠癌根治术患者随机分成 3组：对照组、肠外营养组（ parenteral nutrition, PN组）、肠内营养组（ enteral nutrition, EN组），分别给予普通静脉输液、肠外营养及肠内营养 8天。术前、术后第 1、 3、 6、 9天以碱性磷酸酶－抗碱性磷酸酶（ APAAP）法测定 T淋巴细胞亚群（ CD3、 CD4、 CD8）变化。结果：对照组和 PN组术后 1， 3， 6， 9天 CD3、 CD4阳性细胞数及 CD4/CD8比值与术前比较明显降低 , CD8阳性细胞数明显升高。 EN组术后第 1天 CD3、 CD4阳性细胞数及 CD4/CD8比值明显降低，但自术后第 3天起即开始上升，并逐渐恢复至术前水平。术后第 3、 6、 9天 CD3、 CD4阳性细胞数及 CD4/CD8比值明显高于对照组和 PN组（ P< 0.05） ,而 CD8阳性细胞数明显低于对照组和 PN组 (P< 0.05)，术后第 9天时 CD4/CD8比值且明显高于术前水平。结论：早期肠内营养可纠正胃肠癌患者术后的 T淋巴细胞免疫抑制状态 ,促进 T淋巴细胞免疫功能的恢复。
Objective： This study was designed to investigate the effects of early enteral nutrition(EN)on T-lymphocyte subsets in postoperative patients with gastrointestinal carcinoma. Methods： Fourty-five patients with gastrointestinal carcinoma were divided into three groups at random after radical resections： control group, PN (parenteral nutrition) group, and EN group. The changes of T-lymphocyte subsets were determined by APAAP (alkaline phosphatase anti-alkaline phosphatase) method before operation and at postoperative day 1,3,6 and 9. Results： The numbers of positive CD3 and positive CD4 cell and CD4/CD8 ratio decreased significantly, and CD8 cell number increased markedly in the control group and PN group after operation. In EN group, the numbers of positive CD3 and positive CD4 cell and CD4/CD8 ratio decreased significantly at the 1st day after operation, but then recovered gradually from the 3th day after operation. The numbers of positive CD3 and positive CD4 cell and CD4/CD8 ratio in EN group were higher than those of in the control group and PN group at the 3th, 6th, 9th day after operation (P< 0.05). Conclusions： Early enteral nutrition can improve T-lymphocyte immune function in postoperative patients with gastrointestinal carcinoma.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2001年第3期294-297,共4页
Chinese Journal of Cancer
关键词
肠内营养
T淋巴细胞亚群
胃肿瘤
肠肿瘤
外科手术
： Enteral nutrition； T-lymphocyte subsets； Gastric carcinoma； Intestinal carcinoma； Surgical operation
