摘要
目的 :评价 5 氟尿嘧啶明胶微球在口腔颌面部动脉的栓塞效果。方法 :在X线监控下 ,对 8只成熟杂种狗颈外动脉分支用 5 氟尿嘧啶明胶微球栓塞 ,并在栓塞后进行动脉血管造影 ,并测量其颈部各主要动脉的血液流速及流量 ,进行统计分析。不同时间取栓塞组织制成石蜡切片 ,HE常规染色 ,光镜下观察。结果 :实验表明 ,被栓塞血管的流量、流速明显降低 ,血管内径增粗 ,临近动脉的血流量则代偿性的增加。组织学观察可以见到微球成簇状堵塞末梢动脉血管 ,达到较为完全的栓塞效果。结论 :5 氟尿嘧啶明胶微球是一种有效的动脉末梢栓塞剂 ,使用安全可靠 ,有望应用于临床。
objective: To evaluate the embolization effect of 5 Fu gelatin microsphere(FGM) in oral and maxillofacial region.Methods: FGM was prepared with drug load of 12% and encapsulation of 85%. After irridiated with 60 Co, FGM was suspended into 76% of meglumine diatrizoate, and then perfused into external maxillary artery and lingual artery in 8 dogs under X ray observation. 4 dogs were used in each artery embolization. Blood flow velocity and volume in the arteries were tested at different time after embolization; all the data were analyzed statistically. The sections of embolized tissue at different time were examined microscopically. Results: Before and 1 h, 48 h and l month after ombolization the blood flow volume(ml/min) in external caroted artery was 43±5.0, 31.0±4.5, 26.5±4.0 and 35.0±30; that in external maxillary artery 5.0±1.5, 0.5±1.0, 2.5±1.0 and 3.0±1.5; in ligual artery 3.5±1.0, 0.5±0.5, 0 and 0; in internal maxillary artery 17.0±4.0, 19.5±4.0, 19.0±4.5 and 21.0±3.5, respectively. Stuff of the cavity of the corresponding arteries by FGM were found with histological examination. Conclusion: FGM can embolize artery completely.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2003年第1期60-62,共3页
Journal of Practical Stomatology
关键词
5-氟尿嘧啶
明胶
微球
栓塞
数字减影血管照影术
Fluorouracil
Gelatin
Microsphere
Embolization
Digital subtraction angiography
