摘要
目的 :探讨治疗乙型肝炎 (乙肝 )及抗肝纤维化的有效方法。方法 :采用前列腺素 E1 (PGE1 )静脉滴注治疗慢性乙肝患者 10 8例 (治疗组 ) ,并与行综合治疗 90例 (对照组 )疗效比较 ;观察两组治疗前、后血清 型前胶原 (PC )、层粘蛋白 (L N)、透明质酸 (HA)、 型胶原 ( - C)、肝功能等指标变化。结果 :治疗组血清肝纤维化指标(PC 、L N、HA、 - C)、丙氨酸转氨酶、天冬氨酸转氨酶、血清总胆红素均明显降低 ,与治疗前及对照组比较差异均有非常显著性意义 (均 P <0 .0 1)。结论 :PGE1
Objective:To explore the effective therapy for chronic hepatitis B and anti hepatic fibrosis. Methods:One hundred and eight patients with chronic hepatitis B in the treatment group were treated with Prostaglandin E 1 and ninety patients in the control group received the treatment of Dimmoniun Glycyrrhiziate (DG). The changes of serum type Ⅲ precollagen (PCⅢ), laminin (LN), hyaluronic acid (HA), type IV collagen (Ⅳ C) and parameters of liver function before and after the treatment were observed. Results:The levels of serum PCⅢ, LN, HA, Ⅳ C, alanine transaminase, aspartase transaminase and total bilirubin were decreased significantly in the treatment group as compared with those in the control group and those before the treatment (P< 0.01) . Conclusion:Prostaglandin E 1 could improve liver function and have anti hepatic fibrosis effect.
出处
《中国中西医结合消化杂志》
CAS
2003年第1期25-26,27,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
乙型肝炎
前列腺素E1
肝纤维化
hepatitis B, chronic
prostaglandin E 1
hepatic fibrosis
