摘要
目的 评价后程加速超分割放疗加高剂量率后装近距离治疗联合化疗治疗N2、N3期鼻咽癌的近期疗效及毒副反应。方法将80例N2、N3期鼻咽癌随机分为后程加速超分割放疗加高剂量率后装近距离治疗联合化疗组(综合组)和单纯放疗组(常规组)。综合组于放疗前先行诱导化疗1次;化疗后先行常规分割照射至鼻咽部剂量为40 GY,缩野后改用加速超分割照射至鼻咽部剂量为67 GY,体外照射结束后加用高剂量率后装腔内治疗1～2次;于后装治疗结束后再行辅助化疗2次。常规组放疗采用常规分割,鼻咽部总剂量为70GY。结果 综合组和常规组鼻咽肿瘤完全消退率分别为92.5％和75％,颈部转移淋巴结控制率为85％和55％(P<0.05),CT扫描检查鼻咽肿瘤完全消退率为72.5％和47.5％(P<0.05)。综合组消化道血液毒性大于常规组,但可耐受。结论后程加速超分割放疗加高剂量率后装近距离治疗联合化疗治疗N2、N3期鼻咽癌可提高鼻咽癌的局部控制率,毒副反应可以耐受。
Objective Evaluation of clinical effects and side reaction by late course accelerated hyperfraction radiotherapy and high dose rat brachytherapy and chemotherapy in the treatment of N2,N3 stage nasopharyngeal carcinoma. Methods A total of 80 patients with N2,N3 stage nasopharyngeal carcinoma were divided randomly into two groups:one was late course accelerated hyperfraction radiotherapy added with high dose rate brachytherapy and chemotherapy (A) another was conventional fractionation (B) .Those in group A firstly received the induction chemotherapy for one cycle,followed by conventional fraction radiotherapy to a dose of 40 gray, then changed into accelerated hyperfraction radiotherapy to a total dose of 67 gray, and used one or two cycles of high dose rate brachytherapy, then used another two cycles of adjuvant chemotherapy. Those in group B were treated by the conventional fractionation radiotherapy to a total dose of 70 gray.Results The complete response rate of the nasopharynx was 92.5% for Group A and 75 % for Group B ( P < 0.05) , The cervical lymph node control rate was 85 % for Group A and 55 % for Group B (p < 0.05) . The complete response rate of the nasopharynx with CT was 72.5 % for Group A and 47.5 % for Group B ( P < 0.05). Conclusion Late course accelerated hyperfractionation radiotherapy with high dose rate brachytherapy and chemotherapy can increase the local control of N2 , N3 stage nasopharyngeal carcinioma, The side reaction of late course accelerated hyperfractionation radiotherapy added with high dose rate brachytherapy and chemotherapy can be endured.
出处
《河南肿瘤学杂志》
2003年第1期34-36,共3页
Henan Journal of Oncology
关键词
鼻咽癌
后程加速超分割
近距离疗法
化学疗法
nasopharyngeal carcinoma
late course accelerated hyperfactionation radiotherapy
brachytherapy
chemotherapy
