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中国人群中甲型肝炎总抗体水平及其免疫性的研究 被引量:6

Evaluation and research on hepatitis A total antibody level and the immunity in heathy Chinese.
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摘要 目的研究我国健康人群中甲型肝炎总抗体水平及其免疫性,以便更好地做好甲型肝炎的防治工作。方法采用法国梅里埃(BioMerieux)公司miniVIDAS全自动免疫荧光分析仪检测296例来我院移民体检的健康人甲型肝炎总抗体水平,分析其阳性率。结果296例标本中,218例HAV总抗体浓度≥20IU/L,阳性率为73.6%;其中有134例>400IU/L,占阳性人数的61.5%,占总人数的45.3%。结果分析显示,老年组中HAV总抗体水平阳性率最高,达91.4%,成人组次之,为74.9%,少儿组阳性率最低,为49.2%。结论我国健康人群中曾获得HAV感染的比率非常高,大多数人都产生了很高浓度的特异性抗体,接受了甲肝病毒被动免疫。此现象应引起足够的重视,做好其防治工作。 Objective To evaluate hep atitis A total antibody level and the immunity in heathy Chinese for better control and pre vention of hepatitis A.Methods The anti-HAV total antibody(HAVT)assay was an au to-mated quantitative enzyme-linked fluorescent assay,performed on mini VIDAS manufactured by BioMerieux,France.HAVT were detected on296healthy persons who came to our hospital for immigration check up.Results Out of296persons,218had HAVT levels equal or above20IU/L,the positive rate was73.6%,and among them,134(61.5%)strong positive.Also,anti-HAV prevalence varied with ages.The HAVT positive of elderly had the highest rate(91.4%),adults had74.9%,and children had the lowest rate(49.2%)respectively.Con clu sions Our country has very high rate of HAV infection,so we have to pay enough attention to it.
出处 《江西医学检验》 2003年第1期1-2,共2页 Jiangxi Journal of Medical Laboratory Sciences
关键词 免疫性 甲肝总抗体 免疫荧光实验 阳性率 Hepatitis A total antibody Enzyme-linked fluorescent assay Positive rate
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  • 1Liaw YF, Yang CY, Chu GM, et al. Appearance and persistence of hepatitis A IgM antibody in acute clinical hepatitis A observed in an outbreak[J]. Infection, 1986,14:156~158.
  • 2Stapleton JT. Host immune response to hepatitis A virus[Z]. J Infect Dis, 1995, 171(suppl 1):S9~14.
  • 3Shapiro CN, Coleman PJ, McQuillan GM, et al.Epidemiology of hepatitis A: seroepidemiologyand risk groups in the USA[Z]. Vaccine, 1992, 10(suppl 1):S59~62.
  • 4Keefe EB. Is hepatitis A more severe in patients with chronic hepatitis B and other chronic liver diseases [J]. Am J Gastroenterol, 1995, 90:201~205.

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