摘要
目的 探讨原发性前列腺印戒细胞癌的临床特点。 方法 分析 2例原发性前列腺印戒细胞癌患者的临床资料 ,结合文献复习讨论。 结果 2例患者年龄分别为 64岁和 73岁 ,临床表现为排尿困难、膀胱刺激症及会阴不适。组织学 :印戒状癌细胞呈圆形 ,胞质丰富透明 ,胞核呈新月状位于细胞一侧 ,核分裂像多见。免疫组化染色PSA( + )、PAP( + )、AR( + )、低分子CK( + ) ,CEA( - )、AB/PAS( - )。 1例D期患者行双侧睾丸切除及氟他胺治疗 ,术后 6个月死于广泛转移 ;1例B2 期患者行根治性前列腺切除、双侧睾丸切除、内分泌和局部放射治疗 ,随访 2 5个月未见复发和转移。 结论 原发性前列腺印戒细胞癌是一种罕见、高度恶性的肿瘤 。
Objective To study the clinical features of primary signet ring cell carcinoma of prostate. Methods 2 cases of primary signet ring cell carcinoma of the prostate were studied and reviewed. Results The age of the 2 patients was 64 and 73.The clinical symptoms were dysuria,vesical irritability and perineum discomfort. Histologically, signet ring cell carcinoma was composed of round cells with abundant-clear cytoplasm and crescent-shaped nuclei on one side.Mitosis were frequently observed.Immunohistochemical testing showed the cancer cell was positive for prostate specific antigen (PSA),prostate acid phosphatase (PAP),AR,cytokeratin and negative for carcinoembryonic antigen (CEA),alcian blue/periodic acid-schiff (AB/PAS).One case (stage D)died 6 months after bilateral orchiectomy and flutamide therapy because of wide-spead metastasis;the other (stage B 2) has been surviving 25 months after radical prostatectomy,bilateral orchiectomy,endocrine therapy and local irradiation ministration. Conclusions Primary signet ring cell carcinoma of the prostate is extremely rare with a high grade of malignancy. The diagnosis depends on histopathologic and immunohistochemical studies.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2003年第2期122-124,共3页
Chinese Journal of Urology
