摘要
目的 探讨芬太尼透皮贴剂与吗啡静注用于术后镇痛效果的比较及其对机体应激状态的影响。方法30例上腹部手术的病人随机分为A、B、C三组,分别予以芬太尼透皮贴剂、吗啡及安慰剂,术后4、8、12、24、48h行VAS评分,记录恶心呕吐等副反应的发生情况,并在术前日及术当日测血浆皮质醇浓度。结果VAS评分,A、B组8、12h明显低于C组（P<0.05）,A、B两组无显著性差异;三组病人的术后血浆皮质醇浓度明显高于术前（P<0.05）,而术后A、B、C三组之间,虽A、B组明显低于C组,但无显著性差异。结论 芬太尼透皮贴剂能有效地缓解术后疼痛,其镇痛效果等同于吗啡,同时不增加副作用的发生率。
Objective To observe the effect of transdermal fentanyl and intravenous morphine on postoperative pain relieve and stress. Methods Thirty patients undergoing upper abdominal surgery were divided into three groups: group A (transdermal fentanyl) , group B (intravenous morphy) , group C (placebo). The VAS was assessed at 4, 8, 12, 24h postoperatively and adverse effects such as nause and vomiting were also recorded. The plasma cortisol was examined on the afternoon of the surgical day and the day before surgery. Results The VAS in group A and B were significently lower than group C at 8, 12h (P < 0. 05). There were no siginificent differences on VAS between group A and B. All patients plasma cortisol were significently increased postoperatively. Although the mean values of group A B were lower than group C, the plasma cortisol was not significently different among three groups. Conclusion The transdermal fentanyl can effectively relieve the postoperative pain with similar analgesic effect and occurrence of adverse events in comparison with morphine.
出处
《上海第二医科大学学报》
CSCD
2002年第6期523-524,527,共3页
Acta Universitatis Medicinalis Secondae Shanghai
