摘要
目的 观察异丙酚与依托咪酯诱导对肾上腺皮质功能的影响。方法 在 2 0例择期手术麻醉的患者中分别对 2 m g/kg异丙酚与 0 .3 m g/kg依托咪酯诱导时血浆皮质醇浓度的变化进行观察。结果 异丙酚组给药后 2 h血浆皮质醇浓度由 (30 8.7± 2 7.4) nm ol/L降至 (2 6 7.7± 31.2 ) nm ol/L ,5 h后升高至 (4 0 0 .2± 2 6 .9) nm ol/L ,2 4h后恢复至给药前水平为 (30 6 .4± 35 .4) nm ol/L ;依托咪酯组给药后 2 h血浆皮质醇浓度由 (30 9.1± 36 .6 ) nm ol/L降至 (115 .9± 2 9.7) nm ol/L ,5 h时维持在 (171.1± 34.7) nm ol/L ,2 4h后恢复至给药前水平为 (311.8± 46 .2 ) nm ol/L。结论 异丙酚诱导对肾上腺皮质功能影响小 ,依托咪酯诱导则造成短暂的肾上腺皮质功能抑制。
To investigate the effect of propofol and etomidate for anesthesia induction on adrenocortical function. Methods The plasma total cortisol concentration was determined in 20 patients who were treated with propofol or etomidate. Results After propofol induction,the plasma total cortisol level decreased from (308.7±27.4)nmol/L to(267.7±31.2)nmol/L at postmedication 2 hours,increased to (400.2±26.9)nmol/L at postmedication 5 hours and restored to premedication level at postmedication 24 hours[(306.4±35.4)nmol/L].After etomidate induction,the plasma total cortisol level decreased from(309.1±36.6)nmol/L to (115.9±29.7)nmol/L at postmedication 2 hours, maintained (171.1±34.7)nmol/L at postmedication 5 hours and restored to premedication level at postmedication 24 hours[(311.8±46.2)nmol/L]. Conclusions Propofol induction has little effect on adrenocortical function whereas etomidate induction inhibits adrenocortical function.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2000年第3期284-286,共3页
Acta Academiae Medicinae Sinicae
