摘要
本文报道大鼠灌胃不同剂量(50—1000mg/kg)的8102和不同时间给药对^(234)Th 的促排效果。8102灌胃1000mg/kg 在2天内尿^(234)Th 排出量为对照组4.6倍;肝、骨、肾组织中蓄积量降低,分别为对照组蓄积量的30%、62%和68%。减少药物的剂量则效果降低。于注入^(234)Th 前1h 或2h 给药可提高促排效果,肝^(234)Th 蓄积量比立即给药组明显减少。延缓给药时间效果下降。文中对8102口服疗效的实用性进行了讨论。
8102,a 1,2-dihydroxy-3,6-bismethylamino diacetic derivative,is a new chelatingagent for decorporation of radionuclides.In this paper,the effectiveness of intragastric administrationof this drug at different doses(50—1000mg/kg of body)and at different times before or after givingthorium-234 in rats was reported.The results show that for rats given intragastricly 1000 mg/kg of8102,the excretion of thorium-234 in urine for first two days is 4.5 times more than that for controlrats and accumulations of thorium—234 in liver,skeleton and kidney for these rats were 30%,62%and 68% as those for control rats,respectively.The effectiveness was reduced with decrease in dosageof 8102.Administration of 8102 at 1 or 2 h before injection of thorium-234 can improve theefffectiveness for decorporation of thorium-234:accumulation of thorium-234 in liver was markedlyless than that for rats given 8102 immediately after injection of thorium-234.Delayed administrationof 8102 resulted in reduction of the effectiveness.The praticality of oral administration of 8102 inclinic for decorporation of radionuclides was discussed.
出处
《辐射防护》
CAS
CSCD
北大核心
1992年第5期373-376,共4页
Radiation Protection
关键词
8102
络合剂
促排药物
钍同位素
Chelating Agent
8102
Thorium-234
Drug for Decorparation of Radionuclides from Body
