摘要
目的 :探讨糖尿病 (DM)对大鼠勃起功能的影响 ,AGES抑制剂治疗是否能提高 DM大鼠的勃起功能。方法 :应用雄性 SD大鼠腹腔内注射链脲佐菌素 (STZ)制造 DM动物模型 ,用胰岛素和二氨基酚嗪 (2 ,3- DAP)对 DM大鼠进行干预治疗 8周、 16周 ,再通过勃起试验来评价其勃起功能。结果 :DM组大鼠勃起次数明显少于对照组 ,合用胰岛素和 2 ,3-DAP组勃起次数明显多于 DM组 (P <0 .0 1)。结论 :DM严重损坏大鼠的勃起功能 。
Objective:To study the effects of diabetes on the erectile function in rats and whether the function of penile erection in diabetic rats was improved by the treatment with inhibitors of AGE S Methods:Male Sprague Dawley rats were injected intraperitoneally with streptozotozin(STZ) to make experimental models of diabetes mellitus(DM).Diabetic rats were treated with insulin and 2,3 DAP for 8 or 16 weeks,then injected with apomorphine in all of the rats,penile erections were observed in order to evaluate their erectile function Results:Compaired with the controls(C group),penile erectile times in the DM rats(D group) were decreased significantly(P<0 01).The above indexes in the diabetic rats treated with insulin and 2,3 DAP together(DID group) were significantly higher than those in D group(P<0 01) Conclusion:Penile erection was seriously impaired in rats with DM,and the function of penile erection in diabetic rats was improved by the treatment with inhibitors of AGE S
出处
《广西医学》
CAS
2003年第2期159-161,共3页
Guangxi Medical Journal
