摘要
目的:探讨大肠癌根治术后介入化疗对癌复发和预后的影响。方法:大肠癌根治术后一个月,根据癌灶位置,经股动脉插管进入肝总动脉、肠系膜上或肠系膜下动脉、髂内动脉,定期灌注抗癌药物。临床应用51例,平均40天进行一次,4～6次为一疗程,观察癌复发和生存时间(观察组)。并对大肠癌根治术后49例全身化疗患者进行比较分析(对照组)。结果:观察组1、3、5年复发率为7.8%(4/51)、23.5%(12/51)、33.3%(17/51);生存率98.0%(50/51)、86.3%(44/51)、72.4%(37/51)。对照组1、3、5年复发率为16.3%(8/49)、38.8%(19/49)、75.5%(37/49);生存率87.8%(45/49)、63.3%(31/49)、43.0%(21/49)。两组比较差异具有显著性。结论:大肠癌根治术后区域动脉灌注化疗是预防癌复发和改善预后的有效手段。
Objective:To evalua te the e ffect of postoperative TAI for prevention and treat-ment of colorectal carcin oma recurrence after radical resection.Methods:In51colorectal cancer patien ts received TAI with seldinger technique,the pipe was inserted into the arteri es that supply tumour with nutrition.Through the pipe,5-Fu,ADM,EPI and C BP were infused into the arter-ies every average40days.Results:The treatmen t group5-year survival rate was72.5%re-spectively while that in the oth er group was43%.The differences between the2groups of patients were statist ically significant (P<0.01).Conclusion:Postoperative TAI possess obvio us effect of prevention of colorectal cancer recurrence.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2003年第1期37-39,共3页
Chinese Journal of Clinical Oncology
关键词
根治术
直肠肿瘤
化疗
区域动脉灌注
肿瘤复发
结肠肿瘤
Colorectal c arcinoma Chemotherapy Transcatheter arterial infusion Recurrence carcinoma
